Browsing by Author "Basina, Oļesja"

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    Iron Deficiency Anaemia and Anaemia of Inflammation in Enteropathies Caused by Commonest Small Intestine Disorders: Current Evidence
    (2022-12) Basina, Oļesja; Derova, Jeļena; Derovs, Aleksejs; Lejniece, Sandra; Department of Internal Diseases; Department of Infectology
    It is no mystery that iron deficiency is the most common anaemia and multiple studies have shown that anaemia is a main factor for decreased quality of life. The focus of our article is an up-to-date review of different enteropathies caused by specific disorders and the prevalence of iron deficiency anaemia (IDA), starting with the understanding of physiology of iron absorption and regulation in the intestine. The pathologies that we tried to cover were celiac disease, Crohn’s disease, nonsteroidal anti-inflammatory drugs (NSAID)-induced enteropathy and protein losing enteropathy. Unfortunately, not everything still understood and questions still remain. The main questions are associated with our understanding of iron regulation beyond the ferroportin-hepcidin axis and what mechanism is behind changes of epithelium in different conditions. Depending on the study and pathology of enteropathy, almost half of the studied patients had iron deficiency anaemia. However, in all enteropathies, IDA is more an additional finding or an additional symptom that needs further investigations. That is why many authors consider that IDA is caused by secondary mechanisms and not enteropathy per se and should be correlating with undernourishment, severe mucosal atrophy, malabsorption, and bleeding.
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    THERAPEUTIC ENDOSCOPY FOLLOWING RADICAL TREATMENT OF UPPER GASTROINTESTINAL TRACT CANCER AT RĪGA EAST UNIVERSITY HOSPITAL
    (2024-08) Markevičs, Konstantīns; Basina, Oļesja; Pokrotnieks, Juris; Lapiņa, Anita; Department of Internal Diseases
    The aim of this study was to evaluate the use of therapeutic endoscopy in Rīga East University Hospital “Gaiļezers” and Oncology Centre of Latvia in oesophageal and gastric cancer patients who underwent radical oesophagectomy and gastrectomy. A group of 22 patients was selected, who underwent oesophagectomy and gastrectomy and had developed complications such as anastamotic leak, anastamotic bleeding and stricture, and required endoscopic intervention. For statistical analysis, IBM SPSS and MS Excel programmes were used. The authors tested for correlation between patient age, diagnosis, stage of cancer, type of surgery, and particular complications, used endoscopic manipulations, repeated procedures, endoscopic success rate and mortality. Age, diagnosis and stage of cancer did not show statistically significant correlation with the previously mentioned factors. The type of surgery had one statistically significant correlation with bleeding complication (Fisher’s Exact test p = 0.040). In the Ivor Lewis oesophagectomy group there were no patients with anastamosis bleeding. The type of surgery had no statistically significant difference in stent placement rate, defect closure, endoscopic dilation, repeated procedures, mortality, and successful endoscopic outcome. Complications in the selected group and efficiency of endoscopic methods were compared to other studies in scientific literature, which showed similar results. It was concluded that in the future, implementation of new endoscopic techniques, such as pENPT, VAC stents, OTSC haemoclips and haemostatic powders, can be used to improve treatment results.